Symptoms and Signs
How do you know if you have leaky gut? Below you’ll find seven leaky gut symptoms and early occurring conditions that may point to an issue with your gut health.
1. Food Sensitivities
Because of the onslaught of toxins that enter the bloodstream, the immune systems of people with intestinal hyperpermeability are on overdrive mass-producing various antibodies, which may make their bodies more susceptible to antigens in certain foods (especially gluten and dairy). In studies involving rats and human children, leaky gut and food allergies have been linked. Allergies are believed to be one of the most common leaky gut symptoms.
2. Inflammatory Bowel Disease
Researchers from Hungary uncovered in 2012 that elevated gut permeability is oftentimes localized to the colon in people suffering from irritable bowel syndrome and ulcerative colitis. As far back as 1988, scientists suggested that Crohn’s disease may be more of a risk for people with leaky gut.
A small study (observing 12 patients) discovered that zinc supplementation may help resolve the tight junction dysfunction in these cases, although more research is required on a larger scale to confirm these results.
3. Autoimmune Disease
The key to understanding how leaky gut can cause an autoimmune disease is through the research done on a protein known as “ZONULIN.” According to a 2011 article published in the journal Physiologic Reviews:
Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur.
Eating gluten may trigger this dangerous cascade. University of Maryland School of Medicine researchers have uncovered that gluten “activates zonulin signaling irrespective of the genetic expression of autoimmunity, leading to increased intestinal permeability to macromolecules.”
The good news is that, at least as far as leaky gut plays a role in autoimmune conditions, it is reversible and could potentially alleviate some of these problematic immune responses.
4. Thyroid Problems
One of the autoimmune diseases that leaky gut syndrome may directly affect is Hashimoto’s disease. Also known as “chronic thyroiditis,” this disorder is displayed with hypothyroidism (low thyroid function), impaired metabolism, fatigue, depression, weight gain and a host of other concerns.
5. Nutrient Malabsorption
In my own patients, I’ve observed various nutritional deficiencies resulting from leaky gut, including vitamin B12, magnesium and digestive enzymes. Those common nutrient deficiencies are one reason why many functional medicine practitioners prescribe a whole-food multivitamin in addition to probiotics for people suffering leaky gut problems.
6. Inflammatory Skin Conditions
First described over 70 years ago, the gut-skin connection theory has described how intestinal hyperpermeability can cause a slew of skin conditions, particularly acne and psoriasis. Creams and drugs with endless lists of (sometimes dangerous) side effects are often prescribed for these skin disorders, yet there has been evidence for several decades that part of the root cause might exist in the gut.
7. Mood Issues and Autism
According to a study published in the journal Neuroendocrinology Letters, leaky gut has been shown to cause various neurocognitive disorders. For example, the inflammatory response characteristic of intestinal hyperpermeability triggers the release of pro-inflammatory cytokines and other chemicals that are thought to induce depression.
A study published in the journal Nutritional Neuroscience described the “vicious circle between immune system impairment and increasing dysbiosis that leads to leaky gut and neurochemical compounds and/or neurotoxic xenobiotics production and absorption.”
The authors go on to describe findings from a number of studies that point to their theory that autism may be connected to problems in the gut microbiome, particularly within the first year of life. It is actually a common hypothesis in modern science that leaky gut is strongly related to autism.Credit Dr, Axe
What the Medical Community Has to Say About Leaky Gut Syndrome
Do most conventional doctors support the idea that leaky gut is real?
Because much of the medical community denies leaky gut’s very existence, it’s critical that you understand what leaky gut is and what to look out for in case you or a loved one is affected by it. The good news is that many functional and integrative medicine practitioners have a greater understanding of this condition than they did even a decade ago. They are much more likely to help you determine if you are suffering from leaky gut syndrome and to give you tools to help repair your gut.
How Do You Get Rid of Leaky Gut?
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